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Effect of local desmopressin administration on intraoperative blood loss and quality of the surgical field during functional endoscopic sinus surgery in patients with chronic rhinosinusitis: a triple-blinded clinical trial
Plain-language guide to PMID 31161361 (2019): randomized controlled trial study of Vasopressin and Desmopressin in 90 patients.
Key Facts
- PMID
- 31161361
- Journal
- European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Jahanshahi J et al. (6 authors)
- DOI
- 10.1007/s00405-019-05435-3
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial paper looks at Vasopressin and Desmopressin.
This study aimed to evaluate the effect of local nasal desmopressin premedication on blood loss and the quality of surgical field in functional endoscopic sinus surgery.
Why It Was Studied
Bleeding during functional endoscopic sinus surgery always been a challenge for the quality of surgical field for surgeons.
Who Took Part
The study group was 90 patients.
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
This study was conducted on 90 patients with chronic rhinosinusitis who were candidate for endoscopic sinus surgery.
How the Study Was Run
The researchers set it up as a randomized study.
Random assignment meant chance, not the researchers, decided who got Vasopressin and who got the comparison, which limits bias.
They were randomly assigned to two study groups.
Blood loss and the quality surgical field were determined in 15, 30, 60 and 90 min during the surgery (scoring by BOEZAART grading system).
What Was Measured
PubMed files the paper under topics including Blood Loss, Surgical, Chronic Disease, Deamino Arginine Vasopressin, Drug Monitoring, Endoscopy, Hemostatics and Intraoperative Care.
The authors tagged it with the keywords Desmopressin, Endoscopic sinus surgery and Surgical field.
What This Means in Plain Language
The paper is a randomized study of Vasopressin and Desmopressin in 90 patients.
The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2019 (European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery), a journal based in Germany.
More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.
Our Notes on the Compounds
Vasopressin: A 9-amino-acid hormone (antidiuretic hormone) that controls water balance and blood vessel tone; used in septic shock.
Desmopressin: A synthetic vasopressin analog (DDAVP) used for bedwetting, diabetes insipidus and some bleeding disorders.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.