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Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.
Plain-language guide to PMID 31199458 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 52 adults.
Key Facts
- PMID
- 31199458
- Journal
- The Journal of clinical endocrinology and metabolism
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Martineau AR et al. (8 authors)
- DOI
- 10.1210/jc.2019-00207
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
To compare the influence of administering vitamin D2 vs vitamin D3 on metabolism of vitamin D3.
Pairwise before vs after comparisons were made to evaluate effects of vitamin D2 and vitamin D3 on metabolism of vitamin D.
Why It Was Studied
Vitamin D2 and vitamin D3 have been hypothesized to exert differential effects on vitamin D metabolism.
Who Took Part
According to the abstract, 52 adults were involved.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
Mean postsupplementation metabolite-to-parent ratios were then compared between groups.
How the Study Was Run
The researchers set it up as a randomized and double-blind study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the adults nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity.
What Was Measured
PubMed files the paper under topics including 24,25-Dihydroxyvitamin D 3, 25-Hydroxyvitamin D 2, Calcifediol, Cholecalciferol, Dietary Supplements, Ergocalciferols and Vitamins.
What This Means in Plain Language
The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 52 adults.
Its findings take up roughly 7 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2019 (The Journal of clinical endocrinology and metabolism), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.