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Serum Vitamin D and Age-Related Muscle Loss in Afro-Caribbean Men: The Importance of Age and Diabetic Status.
Plain-language guide to PMID 31237313 (2019): observational study of Vitamin D, K2, Magnesium and Zinc in 574 men.
Key Facts
- PMID
- 31237313
- Journal
- The Journal of frailty & aging
- Year
- 2019
- Study type
- Observational Study
- Authors
- Hwang J et al. (7 authors)
- DOI
- 10.14283/jfa.2018.40
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as an observational study.
To examine the association between baseline serum 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)2D), and prospective change in lean mass with aging in African ancestry population.
The researchers also determined if associations were modulated by age and diabetes mellitus (DM).
Who Took Part
According to the abstract, 574 men were involved.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, men only.
Data were collected from a random sub-sample of 574 men, participants of the Tobago Bone Health Study (TBHS).
574 Afro-Caribbean men, aged 43+ years (mean age: 59.1 ± 10.5), who were randomly selected as the participants in both the baseline and the follow-up visits.
How the Study Was Run
Changes in dual-energy X-ray absorptiometry (DXA)-measured appendicular lean mass (ALM), and total body lean mass (TBLM) were measured over an average of 6.0 ± 0.5 years.
The associations of 25(OH)D and 1,25(OH)2D with ALM and TBLM were assessed by multiple linear regression model after adjusting for potential confounders.
What Was Measured
PubMed files the paper under topics including Age Distribution, Aging, Black People, Diabetes Mellitus, Muscular Atrophy and Vitamin D.
The authors tagged it with the keywords Lean mass loss, sarcopenia and skeletal muscle.
What This Means in Plain Language
This is an observational study of Vitamin D, K2, Magnesium and Zinc in 574 men.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2019 (The Journal of frailty & aging), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.