Therapeutic Value of Vitamin D as an Adjuvant Therapy in Neonates with Sepsis.

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

The current study aimed to evaluate the therapeutic value of vitamin D supplementation as an adjuvant therapy in neonates with sepsis.

Why It Was Studied

Sepsis is unusual systemic reaction to an ordinary infection, and it probably represents a pattern of response by the immune system to the injury.

Vitamin D is a fat-soluble steroid hormone that contributes to the maintenance of normal calcium homeostasis and skeletal mineralization.

Who Took Part

PubMed tags the participants as both men and women.

This study also included 30 healthy neonates as a control group.

For all patients and controls, serum level of 25 (OH) vitamin D and highly sensitive C reactive protein (hs-CRP) were immunoassayed.

How the Study Was Run

The design is described as randomized.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

This study included 60 neonates with sepsis who were randomly divided into 2 equal groups; group I: 30 neonates with sepsis who received antibiotic only, Group II: 30 neonates with sepsis who received antibiotic therapy and vitamin D.

What Was Measured

PubMed files the paper under topics including Anti-Bacterial Agents, Biomarkers, C-Reactive Protein, Egypt, Predictive Value of Tests, ROC Curve and Sepsis.

Author keywords: Neonatal sepsis, adjuvant, hemophilus influenza, highly sensitive C reactive protein, neonates and vitamin D status.

What This Means in Plain Language

The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Infectious disorders drug targets), a journal based in United Arab Emirates.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.