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The perioperative effect of magnesium sulfate in patients with concentric left ventricular hypertrophy undergoing cardiac surgery: A double-blinded randomized study.
Plain-language guide to PMID 31274484 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 250 patients.
Key Facts
- PMID
- 31274484
- Journal
- Annals of cardiac anaesthesia
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Soliman R et al. (2 authors)
- DOI
- 10.4103/aca.ACA_34_18
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The objective of this study was to assess the cardioprotective effect of magnesium sulfate in patients with left ventricular concentric hypertrophy undergoing cardiac surgery.
Who Took Part
The study group was 250 patients.
By PubMed's age tags, the people studied were adults, middle-aged adults and older adults, both men and women.
The study included 250 patients.
Group C - the patients who received an equal amount of normal saline.
How the Study Was Run
In design terms this was a randomized and double-blind study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.
The study was a double-blinded randomized study.
This study was conducted at a cardiac center.
The infusion was started 20 min before induction, during surgery, and the first postoperative 24 h.
What Was Measured
PubMed files the paper under topics including Cardiac Surgical Procedures, Cardiotonic Agents, Creatine Kinase, MB Form, Hemodynamics, Hypertrophy, Left Ventricular, Magnesium Sulfate and Perioperative Care.
The authors tagged it with the keywords Adult cardiac surgery, concentric ventricular hypertrophy, creatinine kinase-MB isoenzyme, myocardial protection and troponin I.
What This Means in Plain Language
The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 250 patients.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2019 (Annals of cardiac anaesthesia), a journal based in India.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.