Effects of a Cod Protein Hydrolysate Supplement on Symptoms, Gut Integrity Markers and Fecal Fermentation in Patients with Irritable Bowel Syndrome.

What Was Tested

This randomized controlled trial looks at Copper (Supplement).

The effect of fish peptides in subjects with irritable bowel syndrome (IBS) has not previously been investigated, hence this study aimed to evaluate the effect of a cod protein hydrolysate (CPH) supplement on symptom severity, gut integrity markers and fecal fermentation in IBS-patients.

Why It Was Studied

The primary outcomes were symptom severity evaluated by the IBS severity scoring system (IBS-SSS) and quality of life.

The secondary outcomes included gut integrity markers and pro-inflammatory cytokines in serum, fecal fermentation measured by concentration of short-chain fatty acids (SCFAs) and fecal calprotectin.

Who Took Part

PubMed tags the participants as both men and women.

How the Study Was Run

In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.

The participants were allocated by chance, so the Copper (Supplement) group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Copper (Supplement).

The comparison arm used a placebo, so changes seen with Copper (Supplement) could be set against what happens without it.

Groups ran in parallel: each of the participants stayed in one arm throughout.

The outcomes were evaluated at baseline and the end of the study.

What Was Measured

The primary outcomes were symptom severity evaluated by the IBS severity scoring system (IBS-SSS) and quality of life.

The secondary outcomes included gut integrity markers and pro-inflammatory cytokines in serum, fecal fermentation measured by concentration of short-chain fatty acids (SCFAs) and fecal calprotectin.

The subject headings attached to it are Diet Records, Dietary Supplements, Fatty Acids, Volatile, Feces, Fermentation, Fish Proteins and Gadiformes.

The authors tagged it with the keywords bioactive fish peptide, gut integrity markers, irritable bowel syndrome, low-grade inflammation and short-chain fatty acids.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Copper (Supplement).

The publication is from 2019 (Nutrients), a journal based in Switzerland.

More context: the Copper (Supplement) compound page, all human trials.