← Human Trials & Peer-Reviewed Studies
Effects of l-carnitine supplementation on cardiovascular and bone turnover markers in patients with pemphigus vulgaris under corticosteroids treatment: A randomized, double-blind, controlled trial
Plain-language guide to PMID 31369185 (2019): double-blind randomized controlled trial study of L-Carnitine in 48 patients.
Key Facts
- PMID
- 31369185
- Journal
- Dermatologic therapy
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Yaghubi E et al. (12 authors)
- DOI
- 10.1111/dth.13049
What This Study Did, in Plain Language
What Was Tested
Researchers studied L-Carnitine in this randomized controlled trial publication.
The aim of this study is to evaluate the protective effects of l-carnitine (LC) supplementation in PV patients under corticosteroid treatment.
Why It Was Studied
Pemphigus vulgaris (PV) is a severe, bullous, autoimmune disease of the skin and mucous membranes.
Corticosteroids are usually the main core treatment for controlling PV, which could lead to several side effects such as insulin resistance, osteoporosis, and cardiovascular disorders.
Who Took Part
The study group was 48 patients.
By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got L-Carnitine and who got the comparison, which limits bias.
As a double-blind L-Carnitine study, the assignments were hidden from both participants and investigators until the end.
A placebo (an inactive look-alike) gave the L-Carnitine group a baseline to be compared against.
Serum levels of osteopontin (OPN), bone morphogenic protein 4 (BMP4), cystatin C, systolic and diastolic blood pressure, 25 hydroxyvitamin D3, and LC were evaluated at the beginning and at the end of the study.
What Was Measured
PubMed files the paper under topics including Adrenal Cortex Hormones, Biomarkers, Bone Remodeling, Carnitine, Dietary Supplements, Iran and Pemphigus.
The authors tagged it with the keywords BMP4, cystatin C, l-carnitine, osteopontin and pemphigus vulgaris.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of L-Carnitine in 48 patients.
The publication is from 2019 (Dermatologic therapy), a journal based in United States.
More context: the L-Carnitine compound page, all human trials.
Our Notes on the Compound
L-Carnitine: An amino acid derivative that carries fatty acids into mitochondria for energy production.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.