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Rising Glucagon-Like Peptide 1 Concentrations After Parathyroidectomy in Patients With Primary Hyperparathyroidism
Plain-language guide to PMID 31400574 (2020): pilot observational study of Parathyroid Hormone (PTH 1-84), hyperparathyroidism.
Key Facts
- PMID
- 31400574
- Journal
- The Journal of surgical research
- Year
- 2020
- Study type
- Observational Study
- Authors
- Antonopoulou V et al. (8 authors)
- DOI
- 10.1016/j.jss.2019.07.019
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Parathyroid Hormone (PTH 1-84) in the context of hyperparathyroidism, published as an observational study.
The aim of this pilot study was to compare glucose-stimulated incretin secretion (GSIS) in patients with asymptomatic primary hyperparathyroidism with normal glucose homeostasis, before and after PTX.
Why It Was Studied
Accordingly, the impact of PTX on glucose-stimulated incretin (glucagon-like peptide 1 [GLP-1] and gastric inhibitory peptide) secretion has not been evaluated.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
Fourteen patients were included in the study.
Homeostasis Model Assessment 2, QUICKI, and Matsuda indexes were used as markers of insulin sensitivity and resistance before and after PTX.
How the Study Was Run
The design is described as pilot.
It is described as a pilot, a small early test of whether a larger Parathyroid Hormone (PTH 1-84) study would be practical.
Fasting calcium, parathyroid hormone, glucose, insulin, GLP-1, and gastric inhibitory peptide were measured pre- and post-operatively.
OGTT measurements were repeated 6 ± 2 wk post-PTX.
What Was Measured
Accordingly, the impact of PTX on glucose-stimulated incretin (glucagon-like peptide 1 [GLP-1] and gastric inhibitory peptide) secretion has not been evaluated.
Topics PubMed links to this paper include Blood Glucose, Fasting, Glucagon-Like Peptide 1, Glucose Tolerance Test, Hyperparathyroidism, Primary, Parathyroid Hormone and Parathyroidectomy.
Author keywords: Glucose metabolism, Insulin resistance and Primary hyperparathyroidism.
What This Means in Plain Language
The paper is a pilot study of Parathyroid Hormone (PTH 1-84) in people with hyperparathyroidism.
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2020 (The Journal of surgical research), a journal based in United States.
More context: the Parathyroid Hormone (PTH 1-84) compound page, Hyperparathyroidism research.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.