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Effect of Monthly High-Dose Vitamin D Supplementation on Acute Respiratory Infections in Older Adults: A Randomized Controlled Trial.
Plain-language guide to PMID 31420647 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 5110 adults.
Key Facts
- PMID
- 31420647
- Journal
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Camargo CA et al. (8 authors)
- DOI
- 10.1093/cid/ciz801
What This Study Did, in Plain Language
What Was Tested
Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.
Who Took Part
According to the abstract, 5110 adults were involved.
The age groups tagged for this paper are middle-aged adults, older adults and people over 80, both men and women.
The researchers performed a randomized, double-blinded, placebo-controlled trial of 5110 adults aged 50-84 years.
Cox models analyzed time to first ARI (upper or lower) by treatment group.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
Blinding on both sides kept the adults and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
What Was Measured
Topics PubMed links to this paper include Australia, Cholecalciferol, Dietary Supplements, Respiratory Tract Infections, Vitamin D and Vitamin D Deficiency.
Author keywords: acute respiratory infection, adults and randomized controlled trial.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 5110 adults.
With several hundred people or more, it is a fairly large study for this kind of research.
Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2020 (Clinical infectious diseases : an official publication of the Infectious Diseases Society of America), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.