The Hemostatic Effect of Desmopressin on Bleeding as a Nasal Spray in Open Septorhinoplasty

What Was Tested

The paper reports a study of Vasopressin and Desmopressin, published as a randomized controlled trial.

This journal requires that authors assign a level of evidence to each article.

For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

Who Took Part

PubMed tags the participants as both men and women.

Conducting an interventional study in their hospital, all patient data including demographic information, medical history and laboratory tests before surgery were collected.

Patients who were randomly divided into two study groups, received nasal desmopressin spray or placebo spray, 60 min before starting open septorhinoplasty.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The participants were allocated by chance, so the Vasopressin group and the comparison group should start out alike.

Blinding on both sides kept the participants and researchers unaware of who received Vasopressin.

A placebo (an inactive look-alike) gave the Vasopressin group a baseline to be compared against.

The measured variables included: bleeding volume, the operative field quality in regard to bleeding (Boezaart score), the surgeons' satisfaction in regard to bleeding during surgery (Likert scale), postoperative bruising, postoperative bleeding and menstruation.

What Was Measured

This journal requires that authors assign a level of evidence to each article.

Topics PubMed links to this paper include Deamino Arginine Vasopressin, Hemorrhage, Hemostatics, Intraoperative Complications, Nasal Sprays, Postoperative Hemorrhage and Rhinoplasty.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vasopressin and Desmopressin.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (Aesthetic plastic surgery), a journal based in United States.

More context: the Vasopressin compound page and the Desmopressin compound page, all human trials.