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Vitamin D and cause-specific vascular disease and mortality: a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults.
Plain-language guide to PMID 31466528 (2019): randomized observational study of Vitamin D, K2, Magnesium and Zinc in 99,012 adults.
Key Facts
- PMID
- 31466528
- Journal
- BMC medicine
- Year
- 2019
- Study type
- Observational Study
- Authors
- Huang T et al. (18 authors)
- DOI
- 10.1186/s12916-019-1401-y
What This Study Did, in Plain Language
What Was Tested
This observational study looks at Vitamin D, K2, Magnesium and Zinc.
Therefore, the researchers examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans.
Who Took Part
The study group was 99,012 adults.
PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.
The researchers used a Mendelian randomisation (MR) design in the China Kadoorie Biobank, the Copenhagen City Heart Study, and the Copenhagen General Population Study.
The 25(OH)D-related genetic variants in the CYP2R1 and DCHR7 genes were genotyped in 99,012 Chinese adults and 106,911 Danish adults.
How the Study Was Run
In design terms this was a randomized study.
The adults were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
What Was Measured
Therefore, the researchers examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans.
The subject headings attached to it are Asian People, China, Genotype, Lipids, Mendelian Randomization Analysis, Vascular Diseases and Vitamin D.
The authors tagged it with the keywords Cardiovascular diseases, Causal effect and Mendelian randomisation.
What This Means in Plain Language
The paper is a randomized study of Vitamin D, K2, Magnesium and Zinc in 99,012 adults.
With several hundred people or more, it is a fairly large study for this kind of research.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2019 (BMC medicine), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.