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Vitamin D status in patients with systemic lupus erythematosus (SLE): A systematic review and meta-analysis.
Plain-language guide to PMID 31520805 (2019): meta-analysis of Vitamin D, K2, Magnesium and Zinc, lupus (sle).
Key Facts
- PMID
- 31520805
- Journal
- Autoimmunity reviews
- Year
- 2019
- Study type
- Meta-Analysis
- Authors
- Islam MA et al. (5 authors)
- DOI
- 10.1016/j.autrev.2019.102392
What This Paper Covers, in Plain Language
What It Covers
Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of lupus (sle) in this meta-analysis publication.
The aim of this systematic review and meta-analysis was to evaluate the serum levels of vitamin D in patients with SLE in compared to healthy controls.
Why It Was Studied
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease where chronic inflammation and tissue or organ damage is observed.
Due to various suspected causes, inadequate levels of vitamin D (a steroid hormone with immunomodulatory effects) has been reported in patients with SLE, however, contradictory.
Who the Included Studies Covered
PubMed, SCOPUS, ScienceDirect and Google Scholar electronic databases were searched systematically without restricting the languages and year (up to March 2, 2019) and studies were selected based on the inclusion criteria.
How the Review Was Done
Different subgroup and sensitivity analyses were conducted.
Study quality was assessed by the modified Newcastle-Ottawa Scale (NOS) and publication bias was evaluated by a contour-enhanced funnel plot, Begg's and Egger's tests.
What Was Measured
Due to various suspected causes, inadequate levels of vitamin D (a steroid hormone with immunomodulatory effects) has been reported in patients with SLE, however, contradictory.
PubMed files the paper under topics including Case-Control Studies, Lupus Erythematosus, Systemic, Vitamin D and Vitamins.
Author keywords: 25(OH)D, Meta-analysis, Systematic review and Systemic lupus erythematosus (SLE).
What This Means in Plain Language
This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc in people with lupus (sle).
The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2019 (Autoimmunity reviews), a journal based in Netherlands.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Lupus (SLE) research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.