← Human Trials & Peer-Reviewed Studies
Effects of High-Dose Vitamin D Replacement on the Serum Levels of Systemic Inflammatory Biomarkers in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease.
Plain-language guide to PMID 31550915 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc, chronic and systemic inflammation.
Key Facts
- PMID
- 31550915
- Journal
- COPD
- Year
- 2019
- Study type
- Randomized Controlled Trial
- Authors
- Dastan F et al. (5 authors)
- DOI
- 10.1080/15412555.2019.1666812
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc in the context of chronic and systemic inflammation, published as a randomized controlled trial.
Secondary outcomes included the length of hospital stay (LOS) and 30-day mortality rates.
Who Took Part
The age groups tagged for this paper are middle-aged adults and older adults, both men and women.
How the Study Was Run
The design is described as randomized, double-blind and placebo-controlled.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
Primary outcomes included inflammation resolution dynamics, which were assessed by monitoring the serum levels of IL-6, IL-8, and hs-CRP.
Symptom recovery was evaluated based on the modified Medical Research Council (mMRC) dyspnea scale on the 1st and 6th days of admission.
What Was Measured
Secondary outcomes included the length of hospital stay (LOS) and 30-day mortality rates.
PubMed files the paper under topics including Biomarkers, C-Reactive Protein, Disease Progression, Inflammation, Interleukin-6, Interleukin-8 and Pulmonary Disease, Chronic Obstructive.
Author keywords: Chronic Obstructive Pulmonary Disease (COPD), exacerbation and vitamin D.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in people with chronic and systemic inflammation.
The publication is from 2019 (COPD), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, Chronic and systemic inflammation research.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.