Magnesium-Based Resorbable Scaffold Versus Permanent Metallic Sirolimus-Eluting Stent in Patients With ST-Segment Elevation Myocardial Infarction: The MAGSTEMI Randomized Clinical Trial.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

Therefore, this study aimed to compare the in-stent/scaffold vasomotion between MgBRS and permanent metallic sirolimus-eluting stent (SES) at 12-month follow-up in ST-segment-elevation myocardial infarction patients.

Why It Was Studied

Magnesium-based bioresorbable scaffold (MgBRS) presents a short resorption period (<1 year) and have the potential of being thromboresistant and exhibiting early restoration of vasomotor function.

To date, however, no randomized clinical trial has investigated the performance of MgBRS.

Who Took Part

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

This investigator-driven, multicenter, randomized, single-blind, controlled trial randomized ST-segment-elevation myocardial infarction patients 1:1 to SES or MgBRS at 11 academic centers.

Besides, endothelial-dependent vasomotor response to acetylcholine (ie, endothelial function) was also assessed in a subgroup of patients (n=69).

How the Study Was Run

In design terms this was a randomized, single-blind and multicenter study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In this single-blind Vitamin D, K2, Magnesium and Zinc study one party knew the assignments and the other did not.

More than one site took part, so the participants came from several places.

The main secondary end points included angiographic parameters of restenosis, device-oriented composite end point, their individual components, and device thrombosis rate.

What Was Measured

Topics PubMed links to this paper include Absorbable Implants, Acetylcholine, Angioplasty, Balloon, Coronary, Coronary Angiography, Coronary Restenosis, Drug-Eluting Stents and Endothelium, Vascular.

Author keywords: STEMI, stents, drug-eluting, tissue scaffolds and vascular endothelium-dependent relaxation.

What This Means in Plain Language

The paper is a randomized, single-blind and multicenter study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2019 (Circulation), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.