Value of N-Terminal Pro-Brain Natriuretic Peptide in Predicting Perioperative Complications Following Spine Surgery

What Was Tested

The paper reports a study of BNP (Nesiritide), published as a observational study.

The utility of preoperative biomarkers for assessing perioperative complications in patients undergoing spine surgery (SS) is unclear, and no study has assessed the ability of preoperative natriuretic peptides to predict adverse events following SS.

This study aimed to evaluate the prognostic importance of N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients undergoing SS.

Who Took Part

The study group was 154 patients.

PubMed indexes the participants as adults, middle-aged adults and older adults, both men and women.

The researchers prospectively followed 154 consecutive adult patients ≥50 years old hospitalized for elective SS.

How the Study Was Run

The outcomes of interest were length of stay in hospital and perioperative medical complications during hospitalization, defined as pneumonia, deep or organ space surgical site infection, bacteremia, prolonged mechanical ventilation >48 hours, unplanned reintubation, acute renal failure, sepsis or septic shock, venous thromboembolism (deep vein thrombosis or pulmonary embolism), cardiac arrest, stroke, myocardial infarction, return to operating room, and in-hospital mortality.

What Was Measured

The subject headings attached to it are Biomarkers, Natriuretic Peptide, Brain, Orthopedic Procedures, Peptide Fragments, Postoperative Complications, Predictive Value of Tests and Spine.

Author keywords: Medical adverse events, N-terminal pro-brain natriuretic peptide and Spine surgery.

What This Means in Plain Language

This is a observational study of BNP (Nesiritide) in 154 patients.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (World neurosurgery), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.