Effect of Vitamin B12 Levels on the Association Between Folic Acid Treatment and CKD Progression: A Post Hoc Analysis of a Folic Acid Interventional Trial.

What Was Tested

Researchers studied Cyanocobalamin (Vitamin B12) in this randomized controlled trial publication.

In populations with folic acid fortification or supplementation, the main nutritional determinant of total homocysteine levels is vitamin B12 (B12) status.

The researchers aimed to evaluate the modifying effect of B12 levels on the association between folic acid treatment and chronic kidney disease (CKD) progression.

Why It Was Studied

The analysis is post hoc and event rate is low.

Government funding (National Key Research and Development Program of China).

Who Took Part

According to the abstract, 1,374 adults were involved.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

How the Study Was Run

The design is described as randomized and double-blind.

Random assignment meant chance, not the researchers, decided who got Cyanocobalamin (Vitamin B12) and who got the comparison, which limits bias.

Neither the adults nor the staff measuring them knew who was on Cyanocobalamin (Vitamin B12), so expectations could not easily colour the readings.

A post hoc analysis of an interventional trial.

What Was Measured

Topics PubMed links to this paper include Disease Progression, Folic Acid, Glomerular Filtration Rate, Renal Insufficiency, Chronic, Vitamin B 12 and Vitamin B Complex.

Author keywords: B12 deficiency, CKD progression, Vitamin B(12), chronic kidney disease (CKD), eGFR decline and enalapril.

What This Means in Plain Language

The paper is a randomized and double-blind study of Cyanocobalamin (Vitamin B12) in 1,374 adults.

With several hundred people or more, it is a fairly large study for this kind of research.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (American journal of kidney diseases : the official journal of the National Kidney Foundation), a journal based in United States.

More context: the Cyanocobalamin (Vitamin B12) compound page, all human trials.