Mid-life serum Vitamin D concentrations were associated with incident dementia but not late-life neuropsychological performance in the Atherosclerosis Risk in Communities (ARIC) Study.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a clinical trial.

For the primary cognitive analyses, the researchers imputed for missing covariates and outcomes and used linear regression to evaluate non-concurrent cross-sectional associations of mid-life 25(OH) D (visit 2) with late-life neuropsychological outcomes (visit 5).

The researchers also used Cox regression models to examine associations of mid-life 25(OH) D and incident dementia.

Why It Was Studied

Activated Vitamin D has anti-inflammatory properties and adequate 25-hydroxyvitamin D [25(OH)D] concentrations may be important for neurocognitive function and protection against neurologic injury.

Registered on clinicaltrials.gov NCT00005131.

Who Took Part

PubMed indexes the participants as middle-aged adults and older adults, both men and women.

Over the next ~ 20 years through visit 5 (2011-2013), participants underwent 3 additional in-person visits, annual telephone calls, and hospitalization surveillance.

Diagnoses of dementia were adjudicated by expert clinician committee.

How the Study Was Run

An extensive battery of neuropsychological outcomes were assessed at visit 5 using standardized protocols.

What Was Measured

The subject headings attached to it are Black or African American, Cohort Studies, Cross-Sectional Studies, Dementia, Neuropsychological Tests, Vitamin D and White People.

The authors tagged it with the keywords Cerebrovascular disease, Cognitive function and Vascular risk factors.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (BMC neurology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.