Comparative study between intrathecal dexmedetomidine and intrathecal magnesium sulfate for the prevention of post-spinal anaesthesia shivering in uroscopic surgery; (RCT).

Plain-language guide to PMID 31651246 (2019): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 105 patients.

Key Facts

PMID: 31651246
Journal: BMC anesthesiology
Year: 2019
Study type: Randomized Controlled Trial
Authors: Omar H et al. (12 authors)
DOI: 10.1186/s12871-019-0853-0

What This Study Did, in Plain Language

What Was Tested

This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.

Hypothermia and shivering are common complications after spinal anaesthesia, especially after uroscopic procedures in which large amounts of cold intraluminal irrigation fluids are used.

Clinical trial registration ID: Pan African Clinical Trial Registry (PACTR) Trial Number PACTR201801003001727; January 2018, "retrospectively registered".

Who Took Part

The study group was 105 patients.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

This prospective randomized, double-blinded controlled study included 105 patients who were scheduled for uroscopic surgery at the Kasr El-Aini Hospital.

The patients were randomly allocated into three groups.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

The patients were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

Neither the patients nor the staff measuring them knew who was on Vitamin D, K2, Magnesium and Zinc, so expectations could not easily colour the readings.

The primary outcomes were the incidence and intensity of shivering.

The secondary outcomes were the incidence of hypothermia, sedation, the use of meperidine to control shivering and complications.

What Was Measured

PubMed files the paper under topics including Adrenergic alpha-2 Receptor Agonists, Anesthesia, Spinal, Anesthetics, Anesthetics, Local, Bupivacaine, Dexmedetomidine and Hypothermia.

Author keywords: Magnesium and Shivering.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 105 patients.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (BMC anesthesiology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.