Vitamin D insufficiency increases risk of chronic pain among African Americans experiencing motor vehicle collision.

What Was Tested

This observational study looks at Vitamin D, K2, Magnesium and Zinc in the context of chronic pain: fibromyalgia & crps.

In this prospective multicenter study, the researchers tested the hypothesis that African Americans (n = 133) presenting to the emergency department after MVC with low peritraumatic vitamin D levels would have worse chronic musculoskeletal pain outcomes compared to individuals with sufficient vitamin D.

In secondary analyses, the researchers assessed for evidence that the effect of vitamin D on post-MVC pain outcomes is mediated, at least in part, by the influence of vitamin D on genetic variants in genes involved in immune system regulation (IL-10 and NLRP3).

Who Took Part

The age groups tagged for this paper are adults and middle-aged adults, both men and women.

How the Study Was Run

In design terms this was a multicenter study.

Running at several centres spread the Vitamin D, K2, Magnesium and Zinc study over different clinics and patient groups.

Vitamin D levels were assessed in the early aftermath of MVC through enzyme-linked immunosorbent assay, and pain severity was assessed using the 0 to 10 numeric rating scale at 6 weeks, 6 months, and 1 year.

What Was Measured

In this prospective multicenter study, the researchers tested the hypothesis that African Americans (n = 133) presenting to the emergency department after MVC with low peritraumatic vitamin D levels would have worse chronic musculoskeletal pain outcomes compared to individuals with sufficient vitamin D.

In secondary analyses, the researchers assessed for evidence that the effect of vitamin D on post-MVC pain outcomes is mediated, at least in part, by the influence of vitamin D on genetic variants in genes involved in immune system regulation (IL-10 and NLRP3).

The subject headings attached to it are Accidents, Traffic, Black or African American, Back Pain, Chronic Pain, Genetic Predisposition to Disease, Interleukin-10 and Musculoskeletal Pain.

What This Means in Plain Language

The paper is a multicenter study of Vitamin D, K2, Magnesium and Zinc in people with chronic pain: fibromyalgia & crps.

The publication is from 2020 (Pain), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Chronic pain: fibromyalgia & CRPS research.