Zinc supplements and bone health: The role of the RANKL-RANK axis as a therapeutic target.

What It Covers

The paper reports a study of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement), published as a review.

Therefore, the aim of the study was to conduct a review to investigate the possible effect of the zinc mediated bone remodeling via RANKL/RANK/OPG pathway.

Why It Was Studied

The influence of zinc on bone turnover could be facilitated via regulating RANKL/RANK/OPG pathway in bone tissue.

Who the Included Studies Covered

Subsequently, the details of the pathway and the impact of zinc supplements on RANKL/RANK/OPG pathway regulation were discussed.

How the Review Was Done

A comprehensive systematic search was performed in MEDLINE/PubMed, Cochrane Library, SCOPUS, and Google Scholar to explore the studies investigating the effect of zinc as a bone remodeling factor via RANKL/RANK/OPG pathway regulation.

What Was Measured

Topics PubMed links to this paper include Bone Density, Bone and Bones, Osteoprotegerin, RANK Ligand, Receptor Activator of Nuclear Factor-kappa B and Zinc.

The authors tagged it with the keywords Bone health, Bone remodeling, RANKL/RANK/OPG system and Zinc supplement.

What This Means in Plain Language

This is a review of Vitamin D, K2, Magnesium and Zinc and Copper (Supplement).

Results are reported in around 9 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)), a journal based in Germany.

More context: the Vitamin D, K2, Magnesium and Zinc compound page and the Copper (Supplement) compound page, all human trials.