Difference in the Effects of Lidocaine With Epinephrine and Prilocaine With Felypressin on the Autonomic Nervous System During Extraction of the Impacted Mandibular Third Molar: A Randomized Controlled Trial

What Was Tested

The paper reports a study of Felypressin, published as a randomized controlled trial.

The commonly used local anesthetic preparations are lidocaine to which the vasoconstrictor epinephrine is added (lidocaine-epinephrine) and prilocaine to which the vasoconstrictor felypressin is added (prilocaine-felypressin); however, their effects during dental treatment are unclear.

The researchers examined the effects of these 2 different local anesthetic preparations on the autonomic nervous system and circulation during extraction of the impacted mandibular third molar.

Who Took Part

According to the abstract, 40 patients were involved.

PubMed tags the participants as women only.

In this randomized controlled trial, 40 female patients scheduled for extraction of an impacted mandibular third molar were randomized to the lidocaine-epinephrine group or prilocaine-felypressin group.

Heart rate variability, heart rate, and systolic blood pressure were recorded during the experiment.

How the Study Was Run

The design is described as randomized.

The patients were allocated by chance, so the Felypressin group and the comparison group should start out alike.

Descriptive and bivariate statistics were computed, and the P value was set at .05.

What Was Measured

Topics PubMed links to this paper include Anesthesia, Dental, Anesthetics, Local, Autonomic Nervous System, Epinephrine, Felypressin, Lidocaine and Molar, Third.

What This Means in Plain Language

The paper is a randomized study of Felypressin in 40 patients.

Results are reported in around 5 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons), a journal based in United States.

More context: the Felypressin compound page, all human trials.