[Clinical randomized controlled trial on influence of recombinant human growth hormone on the immune function of younger children with severe burn injuries].

What Was Tested

Researchers studied Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in this randomized controlled trial publication.

Objective: To preliminarily investigate the influence of recombinant human growth hormone (rhGH) on the immune function of younger children with severe burn injuries.

Why It Was Studied

Methods: A total of 30 younger children with severe burn injuries, conforming to the study criteria, were admitted to their hospital from July 2016 to July 2018.

The patients in control group received anti-shock, anti-infection, and wound caring therapies, etc.

Who Took Part

The study group was 30 children.

PubMed indexes the participants as infants, young children and children, both men and women.

They were enrolled in the prospective, randomized, double-blinded, controlled trial and divided into group rhGH [n=15, 10 boys and 5 girls, aged (22±10) months] and control group [n=15, 8 boys and 7 girls, aged (21±7) months] according to the random number table.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Random assignment meant chance, not the researchers, decided who got Exogenous HGH, sermorelin & older GHRPs (why they're passed over) and who got the comparison, which limits bias.

Neither the children nor the staff measuring them knew who was on Exogenous HGH, sermorelin & older GHRPs (why they're passed over), so expectations could not easily colour the readings.

What Was Measured

Blood glucose level was detected by glucometer.

Data were processed with Fisher's exact probability test, independent sample t test, analysis of variance for repeated measurement and Bonferroni correction, and Mann-Whitney U test.

Topics PubMed links to this paper include Burns, Human Growth Hormone, Recombinant Proteins and T-Lymphocytes.

The authors tagged it with the keywords Immunomodulation.

What This Means in Plain Language

The paper is a randomized and double-blind study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over) in 30 children.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2019 (Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns), a journal based in China.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.