Paradoxical Response of Parathyroid Hormone to Vitamin D-Calcium Supplementation in Indian Children

What Was Tested

This randomized controlled trial paper looks at Parathyroid Hormone (PTH 1-84).

To investigate the effect of oral vitamin D-calcium supplementation on serum intact parathyroid hormone (PTH), calcium, phosphorous, and alkaline phosphatase (ALK-P) concentrations in children with habitually low calcium intakes.

In this follow-up study to a randomized controlled trial that aimed to assess the effect of vitamin D-calcium supplementation on immunity, data related to dietary intake, anthropometry, and biochemistry [serum 25(OH)D and bone profile] were collected from 178 children-79 in the vitamin D group and 99 in the non-vitamin D group.

Who Took Part

The study group was 178 children.

By PubMed's age tags, the people studied were children, both men and women.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

The children were allocated by chance, so the Parathyroid Hormone (PTH 1-84) group and the comparison group should start out alike.

Neither the children nor the staff measuring them knew who was on Parathyroid Hormone (PTH 1-84), so expectations could not easily colour the readings.

What Was Measured

The subject headings attached to it are Calcium, Deficiency Diseases, Dietary Supplements, Food-Drug Interactions, Parathyroid Hormone, Vitamin D and Vitamin D Deficiency.

Author keywords: calcium to phosphorus ratio, undernourished and vitamin D sufficient.

What This Means in Plain Language

The paper is a randomized and double-blind study of Parathyroid Hormone (PTH 1-84) in 178 children.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (The Journal of pediatrics), a journal based in United States.

More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.