The effects of grape seed extract (Vitis vinifera) supplement on inflammatory markers, neuropeptide Y, anthropometric measures, and appetite in obese or overweight individuals: A randomized clinical trial

What Was Tested

This randomized controlled trial paper looks at Neuropeptide Y.

This study aimed to evaluate the effects of GSE supplementation on inflammatory markers, neuropeptide Y, anthropometric measurements, and appetite in obese or overweight individuals.

Who Took Part

According to the abstract, 40 subjects were involved.

The age groups tagged for this paper are adults, both men and women.

Both groups were under a restricted calorie diet (RCD)(~250 kcal lower than the estimated energy requirement).

Anthropometric measurements, biochemical biomarkers and dietary intakes were determined during the study period.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

The subjects were allocated by chance, so the Neuropeptide Y group and the comparison group should start out alike.

Neither the subjects nor the staff measuring them knew who was on Neuropeptide Y, so expectations could not easily colour the readings.

A placebo (an inactive look-alike) gave the Neuropeptide Y group a baseline to be compared against.

What Was Measured

PubMed files the paper under topics including Appetite, Biomarkers, Body Mass Index, C-Reactive Protein, Caloric Restriction, Dietary Supplements and Grape Seed Extract.

Author keywords: NPY, TNF-α, hs-CRP, inflammation and obesity.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Neuropeptide Y in 40 subjects.

Its findings take up roughly 3 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (Phytotherapy research : PTR), a journal based in England.

More context: the Neuropeptide Y compound page, all human trials.