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Pre-Operative pro-adrenomedullin as a predictor of postoperative requirement of organ support in patients scheduled for major abdominal surgery. A prospective observational pilot study
Plain-language guide to PMID 31757431 (2020): pilot observational study of Adrenomedullin.
Key Facts
- PMID
- 31757431
- Journal
- Revista espanola de anestesiologia y reanimacion
- Year
- 2020
- Study type
- Observational Study
- Authors
- Ramasco Rueda F et al. (5 authors)
- DOI
- 10.1016/j.redar.2019.10.002
What This Study Did, in Plain Language
What Was Tested
Researchers studied Adrenomedullin in this observational study publication.
Mid-Regional-Pro-Adrenomedullin (MR-Pro-ADM) is a marker of severity in a wide spectrum of pathological conditions such as sepsis, and cardiovascular dysfunction.
Its usefulness as a predictor of morbidity and mortality in surgical patients has yet to be elucidated.
Who Took Part
The age groups tagged for this paper are older adults, both men and women.
One centre, pilot, prospective observational cohort study, enrolling adult patients scheduled for major abdominal surgery.
How the Study Was Run
The design is described as pilot.
It is described as a pilot, a small early test of whether a larger Adrenomedullin study would be practical.
The accuracy of the MR-Pro-ADM to predict PROS was determined by area under the receiver operating characteristic curve (AUROC) analysis.
An univariate analysis was performed to identify the association of PROS and the MR-Pro-ADM value with the best combination of sensitivity and specificity.
A multivariate analysis was performed to identify preoperative MR-Pro-ADM as independent risk factor for PROS.
What Was Measured
The subject headings attached to it are Abdomen, Adrenomedullin, Biomarkers, Hospital Mortality, Incidence, Logistic Models and Pilot Projects.
The authors tagged it with the keywords Biomarcador, Perioperative risk, Postoperative requirement of organ support, Proadrenomedulina, Proadrenomedullin and Riesgo perioperatorio.
What This Means in Plain Language
The paper is a pilot study of Adrenomedullin.
Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2020 (Revista espanola de anestesiologia y reanimacion), a journal based in Spain.
More context: the Adrenomedullin compound page, all human trials.
Our Notes on the Compound
Adrenomedullin: A 52-amino-acid peptide that widens blood vessels; studied as an infusion in heart, lung and gut conditions.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.