GnRH agonists to sustain the luteal phase in antagonist IVF cycles: a randomized prospective trial

What Was Tested

This randomized controlled trial looks at Triptorelin.

The aim of the study was to evaluate the effect of triptorelin addition in short antagonist cycles, compared to cycles where the only supplementation was progesterone.

The primary objective of this study was the study of the effect of Triptorelin addiction during the luteal phase on the live birth rate.

Why It Was Studied

The study was approved by the Ethics Committee of Provincia di Bergamo (n 1203/2013).

Who Took Part

By PubMed's age tags, the people studied were adults, women only.

Patients were divided into three groups: a) Regular antagonist protocol, with only luteal progesterone; b) Antagonist protocol with luteal triptorelin as multiple injections, c) Antagonist protocol with luteal triptorelin as single bolus.

How the Study Was Run

The researchers set it up as a randomized study.

The participants were allocated by chance, so the Triptorelin group and the comparison group should start out alike.

The study was a prospective, randomized, open study, performed in two independent Centers from July 2013 to October 2015.

Descriptive statistics were obtained for all the parameters.

Mean and standard deviation were used for all quantitative parameters.

What Was Measured

The subject headings attached to it are Embryo Implantation, Fertilization in Vitro, Gonadotropin-Releasing Hormone, Live Birth, Luteal Phase, Ovarian Hyperstimulation Syndrome and Pregnancy Rate.

The authors tagged it with the keywords GnRH agonist, GnRH antagonist, IVF and Triptorelin.

What This Means in Plain Language

The paper is a randomized study of Triptorelin.

Results are reported in around 7 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2019 (Reproductive biology and endocrinology : RB&E), a journal based in England.

More context: the Triptorelin compound page, all human trials.