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Evaluation of bradykinin, VEGF, and EGF biomarkers in gingival crevicular fluid and comparison of PhotoBioModulation with conventional techniques in periodontitis: a split-mouth randomized clinical trial
Plain-language guide to PMID 31784929 (2020): randomized controlled trial study of Bradykinin.
Key Facts
- PMID
- 31784929
- Journal
- Lasers in medical science
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Angiero F et al. (8 authors)
- DOI
- 10.1007/s10103-019-02919-w
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Bradykinin, published as a randomized controlled trial.
Periodontal disease is a chronic progressive inflammatory process leading to damage of tooth-supporting tissues.
This comparative study assessed the effect of PhotoBioModulation (PBM) versus conventional therapy, and investigated biomarkers involved in the healing process.
Who Took Part
PubMed indexes the participants as adults and middle-aged adults, both men and women.
Patients were treated at baseline, either with scaling and root planing (SRP group) or with a procedure entailing SRP supported by PBM (PBM group).
How the Study Was Run
The researchers set it up as a randomized study.
Because people in this Bradykinin study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
What Was Measured
This comparative study assessed the effect of PhotoBioModulation (PBM) versus conventional therapy, and investigated biomarkers involved in the healing process.
The test group comprised twenty systemically-healthy non-smoking subjects with chronic periodontitis with the presence of two matched contro-lateral premolar sites (probing depth > 5 mm); twenty subjects without chronic periodontitis (CP) served as control group.
PubMed files the paper under topics including Biomarkers, Bradykinin, Epidermal Growth Factor, Gingival Crevicular Fluid, Low-Level Light Therapy, Periodontitis and Vascular Endothelial Growth Factor A.
The authors tagged it with the keywords Dentistry, Diode, Effect of Lasers in Tissue, Lasers, Lasers in Dentistry and Low-level laser therapy.
What This Means in Plain Language
The paper is a randomized study of Bradykinin.
The publication is from 2020 (Lasers in medical science), a journal based in England.
More context: the Bradykinin compound page, all human trials.
Our Notes on the Compound
Bradykinin: A 9-amino-acid peptide that widens blood vessels and causes swelling; given in research studies of blood flow.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.