Magnesium and Ketamine Reduce Early Morphine Consumption After Open Bariatric Surgery: a Prospective Randomized Double-Blind Study.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

This study aims to evaluate the effects of magnesium and ketamine combination on morphine consumption after open bariatric surgery (primary outcome), as well as on postoperative pain scores and occurrence of side effects.

Why It Was Studied

Optimal pain management in bariatric patients is crucial for early recovery.

Who Took Part

According to the abstract, 60 patients were involved.

A total of 60 patients undergoing elective open gastric bypass were randomized into 3 groups.

All patients received the same general anaesthesia protocol.

How the Study Was Run

The design is described as randomized, double-blind and placebo-controlled.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

The ketamine group (K) received the same bolus and infusion of ketamine, together with a bolus and continuous infusion of normal saline.

The placebo group (P) received normal saline.

Morphine consumption, VAS pain scores and occurrence of side effects were recorded for 48 h postoperatively.

What Was Measured

PubMed files the paper under topics including Analgesics, Analgesics, Opioid, Bariatric Surgery, Ketamine, Magnesium, Morphine and Obesity, Morbid.

The authors tagged it with the keywords Obese and Opioid sparing.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 60 patients.

The abstract goes on to report its results in about 5 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (Obesity surgery), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.