The Influence of Perioperative Fluid Therapy on N-terminal-pro-brain Natriuretic Peptide and the Association With Heart and Lung Complications in Patients Undergoing Colorectal Surgery: Secondary Results of a Clinical Randomized Assessor-blinded Multicenter Trial

What Was Tested

The paper reports a study of BNP (Nesiritide), published as a randomized controlled trial.

To investigate the influence of intravenous (iv) fluid volumes on the secretion of N-terminal-pro-brain natriuretic peptide (NT-Pro-BNP) in colorectal surgical patients and its association with cardiopulmonary complications (CPC).

In addition, to examine if preoperative NT-Pro-BNP can predict the risk for postoperative CPC.

Who Took Part

The abstract describes 135 patients taking part.

By PubMed's age tags, the people studied were middle-aged adults and older adults, both men and women.

Blood samples from patients enrolled in a previously published clinical randomized assessor-blinded multicenter trial were analyzed.

Included were adult patients undergoing elective colorectal surgery with the American-Society-of-Anesthesiologists-scores of 1-3.

How the Study Was Run

In design terms this was a randomized, single-blind and multicenter study.

Because people in this BNP (Nesiritide) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

In this single-blind BNP (Nesiritide) study one party knew the assignments and the other did not.

More than one site took part, so the patients came from several places.

Samples from 135 patients were available for analysis.

Patients were allocated to either a restrictive (R-group) or a standard (S-group) iv-fluid regimen, commencing preoperatively and continuing until discharge.

Blood was sampled every morning until the fourth postoperative day.

The primary outcome for this study was NT-Pro-BNP changes and its association with fluid therapy and CPC.

What Was Measured

Topics PubMed links to this paper include Colonic Diseases, Digestive System Surgical Procedures, Fluid Therapy, Heart Diseases, Lung Diseases, Natriuretic Peptide, Brain and Peptide Fragments.

What This Means in Plain Language

The paper is a randomized, single-blind and multicenter study of BNP (Nesiritide) in 135 patients.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Annals of surgery), a journal based in United States.

More context: the BNP (Nesiritide) compound page, all human trials.