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Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment: A Randomized Clinical Trial.
Plain-language guide to PMID 31910279 (2020): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 18 women.
Key Facts
- PMID
- 31910279
- Journal
- JAMA
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Schisterman EF et al. (19 authors)
- DOI
- 10.1001/jama.2019.18714
- Registered trial
- NCT01857310
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
Who Took Part
The study group was 18 women.
The age groups tagged for this paper are teenagers, young adults, adults and middle-aged adults, both men and women.
The Folic Acid and Zinc Supplementation Trial was a multicenter randomized clinical trial.
Couples (n = 2370; men aged ≥18 years and women aged 18-45 years) planning infertility treatment were enrolled at 4 US reproductive endocrinology and infertility care study centers between June 2013 and December 2017.
How the Study Was Run
In design terms this was a randomized, placebo-controlled and multicenter study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
A placebo (an inactive look-alike) gave the Vitamin D, K2, Magnesium and Zinc group a baseline to be compared against.
Running at several centres spread the Vitamin D, K2, Magnesium and Zinc study over different clinics and patient groups.
The last 6-month study visit for semen collection occurred during August 2018, with chart abstraction of live birth and pregnancy information completed during April 2019.
What Was Measured
PubMed files the paper under topics including DNA Fragmentation, Dietary Supplements, Fertilization in Vitro, Folic Acid, Infertility, Male, Live Birth and Semen.
What This Means in Plain Language
The paper is a randomized, placebo-controlled and multicenter study of Vitamin D, K2, Magnesium and Zinc in 18 women.
With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.
The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2020 (JAMA), a journal based in United States.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.