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Changes in the whole/intact parathyroid hormone ratio and their clinical implications in patients with chronic kidney disease
Plain-language guide to PMID 31919783 (2020): observational study of Parathyroid Hormone (PTH 1-84) in 773 patients.
Key Facts
- PMID
- 31919783
- Journal
- Journal of nephrology
- Year
- 2020
- Study type
- Observational Study
- Authors
- Okamoto K et al. (6 authors)
- DOI
- 10.1007/s40620-019-00690-3
What This Study Did, in Plain Language
What Was Tested
Researchers studied Parathyroid Hormone (PTH 1-84) in this observational study publication.
The present study therefore aimed to examine the relationship between w/i PTH ratio and kidney function and determine other factors affecting the w/i PTH ratio.
Why It Was Studied
Although a previous study has reported the relationship between intact parathyroid hormone (iPTH) and whole parathyroid hormone (wPTH) levels in patients undergoing dialysis, the w/i PTH ratio (whole/intact PTH ratio) among predialysis chronic kidney disease (CKD) patients remains unclear.
Who Took Part
The abstract describes 773 patients taking part.
An observational study including 773 predialysis CKD patients was conducted.
How the Study Was Run
The correlation between w/i PTH ratio and kidney function, as well as clinical factors at different CKD stages, were assessed using univariate and multivariate analyses.
What Was Measured
Although a previous study has reported the relationship between intact parathyroid hormone (iPTH) and whole parathyroid hormone (wPTH) levels in patients undergoing dialysis, the w/i PTH ratio (whole/intact PTH ratio) among predialysis chronic kidney disease (CKD) patients remains unclear.
PubMed files the paper under topics including Calcium, Glomerular Filtration Rate, Kidney Failure, Chronic, Kidney Transplantation, Parathyroid Hormone, Renal Dialysis and Renal Insufficiency, Chronic.
The authors tagged it with the keywords Chronic kidney disease, Intact PTH, Whole PTH and whole/intact PTH ratio.
What This Means in Plain Language
This is an observational study of Parathyroid Hormone (PTH 1-84) in 773 patients.
With several hundred people or more, it is a fairly large study for this kind of research.
The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.
The publication is from 2020 (Journal of nephrology), a journal based in England.
More context: the Parathyroid Hormone (PTH 1-84) compound page, all human trials.
Our Notes on the Compound
Parathyroid Hormone (PTH 1-84): The 84-amino-acid hormone that raises blood calcium; full-length PTH (Natpara) has been used in hypoparathyroidism. Teriparatide is its 1-34 fragment.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.