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Effect of vitamin D supplementation on clinical outcome and biochemical profile in South Indian population with vitamin D-deficient chronic urticarial - A randomized double-blind placebo controlled trial.
Plain-language guide to PMID 31926152 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 31926152
- Journal
- Clinica chimica acta; international journal of clinical chemistry
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Mony A et al. (6 authors)
- DOI
- 10.1016/j.cca.2020.01.003
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
Chronic urticaria (CU) is a debilitating inflammatory skin disease.
The researchers assessed the effect of vitamin D supplementation in vitamin D deficient CU patients on the clinical outcome and inflammatory markers in South Indian patients with CU.
Who Took Part
This randomized controlled trial involved 120 vitamin-D deficient CU patients.
How the Study Was Run
The researchers set it up as a randomized, double-blind and placebo-controlled study.
Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.
Blinding on both sides kept the participants and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.
Some participants received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
Urticaria activity score (UAS7) and autologous plasma skin test (APST) status was assessed in all cases.
What Was Measured
The researchers assessed the effect of vitamin D supplementation in vitamin D deficient CU patients on the clinical outcome and inflammatory markers in South Indian patients with CU.
The subject headings attached to it are Dietary Supplements, Inflammation, Urticaria, Vitamin D and Vitamin D Deficiency.
The authors tagged it with the keywords Autoimmune, C-reactive protein, Chronic urticaria, Cytokines, Interleukins and Urticaria activity score.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
Results are reported in around 3 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2020 (Clinica chimica acta; international journal of clinical chemistry), a journal based in Netherlands.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.