← Human Trials & Peer-Reviewed Studies
Vitamin D Supplementation in Overweight/obese Asian Indian Women with Prediabetes Reduces Glycemic Measures and Truncal Subcutaneous Fat: A 78 Weeks Randomized Placebo-Controlled Trial (PREVENT-WIN Trial).
Plain-language guide to PMID 31937856 (2020): open-label randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.
Key Facts
- PMID
- 31937856
- Journal
- Scientific reports
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Bhatt SP et al. (6 authors)
- DOI
- 10.1038/s41598-019-56904-y
What This Study Did, in Plain Language
What Was Tested
This randomized controlled trial looks at Vitamin D, K2, Magnesium and Zinc.
The objectives of this study was to evaluate effect of vitamin D supplementation on glycemic profile and body composition in prediabetic and vitamin D deficient overweight/obese Asian Indian women.
Why It Was Studied
Vitamin D deficiency may contribute to etiology of type 2 diabetes in Asian Indians.
In this open-label randomized placebo-controlled trial (78 weeks duration), 121 females (aged 20-60 years) with prediabetes and vitamin D deficiency were randomly allocated in intervention (n, 61) and placebo (n, 60) groups.
Who Took Part
PubMed indexes the participants as young adults, adults and middle-aged adults, women only.
How the Study Was Run
The researchers set it up as a randomized, open-label and placebo-controlled study.
The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
Nothing was hidden in this open-label Vitamin D, K2, Magnesium and Zinc study: the participants and staff both knew the treatment.
The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.
What Was Measured
The primary outcome variables were fasting blood glucose (FBG), 2-h blood glucose post OGTT (2-h BG), hemoglobin A1c (HbA1C), and reversal to normoglycemia.
The subject headings attached to it are Blood Glucose, Diabetes Mellitus, Type 2, Dietary Supplements, Glycated Hemoglobin, India, Obesity and Overweight.
What This Means in Plain Language
The paper is a randomized, open-label and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.
The publication is from 2020 (Scientific reports), a journal based in England.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.