Synergistic effect of the association between lidocaine and magnesium sulfate on peri-operative pain after mastectomy: A randomised, double-blind trial.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Recently, the use of venous adjuvants, such as lidocaine and magnesium sulfate, has been gaining ground in multimodal analgesia.

However, no study has evaluated the impact a combination of the two drugs.

Who Took Part

One-hundred and ninety-eight patients were electively scheduled for mastectomy.

All patients received standard general anaesthesia.

How the Study Was Run

In design terms this was a randomized, double-blind and parallel-group study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

Groups ran in parallel: each of the participants stayed in one arm throughout.

Hospital de Base do Distrito Federal, Brasilia, Federal District, Brazil from November 2014 to December 2017.

What Was Measured

However, no study has evaluated the impact a combination of the two drugs.

The subject headings attached to it are Analgesics, Opioid, Anesthetics, Local, Brazil, Breast Neoplasms, Lidocaine, Magnesium Sulfate and Mastectomy.

What This Means in Plain Language

The paper is a randomized, double-blind and parallel-group study of Vitamin D, K2, Magnesium and Zinc.

The abstract goes on to report its results in about 7 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (European journal of anaesthesiology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.