Associations between common polymorphisms in CYP2R1 and GC, Vitamin D intake and risk of colorectal cancer in a prospective case-cohort study in Danes.

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a clinical trial.

The association between vitamin D and incidence of colorectal cancer has been thoroughly investigated, but the results are conflicting.

Registered 12 December 2017 (retrospectively registered).

Who Took Part

The study group was 1743 participants.

PubMed indexes the participants as middle-aged adults, both men and women.

A nested case-cohort study of 920 colorectal cancer cases and 1743 randomly selected participants from the Danish prospective "Diet, Cancer and Health" study was performed.

Vitamin D intake from supplements and diet was assessed from a validated food frequency questionnaire.

How the Study Was Run

Genotypes CYP2R1/rs10741657 and GC/rs4588 were determined by PCR-based KASP™ genotyping assay.

What Was Measured

PubMed files the paper under topics including Cholestanetriol 26-Monooxygenase, Colorectal Neoplasms, Cytochrome P450 Family 2, Denmark, Dietary Supplements, Polymorphism, Single Nucleotide and Vitamin D.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc in 1743 participants.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 3 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (PloS one), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.