Secretin effects on gastric functions, hormones and symptoms in functional dyspepsia and health: randomized crossover trial

What Was Tested

This randomized controlled trial paper looks at Secretin.

Their aim was to study the effects of secretin on gastric motility, satiation, postprandial symptoms, and key hormones.

Why It Was Studied

Abnormal gastric accommodation (GA) and gastric emptying contribute to pathophysiology in functional dyspepsia (FD).

Secretin is a key regulator of GA in animal studies.

Who Took Part

The study group was 10 volunteers.

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and crossover.

The volunteers were allocated by chance, so the Secretin group and the comparison group should start out alike.

Neither the volunteers nor the staff measuring them knew who was on Secretin, so expectations could not easily colour the readings.

The comparison arm used a placebo, so changes seen with Secretin could be set against what happens without it.

Each person switched between Secretin and the comparison at some point, usually with a gap in between.

Satiation was measured by volume to fullness (VTF) and maximum tolerated volume (MTV) on an Ensure nutrient drink test and postprandial symptoms 30 min post-MTV.

Fasting and postprandial GLP-1, GIP, and HPP were measured.

What Was Measured

The researchers used measured GA (by validated SPECT method) after a 111In radiolabeled Ensure 300-mL meal and quantified gastric emptying for 30 min by scintigraphy.

PubMed files the paper under topics including Dietary Sucrose, Dyspepsia, Food, Formulated, Gastric Emptying, Meals, Postprandial Period and Satiation.

The authors tagged it with the keywords non-ulcer motility, scintigraphy, stomach and treatment.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Secretin in 10 volunteers.

With fewer than 40 people, it is a small study, so it is better read as an early signal for further research than as a settled answer.

The publication is from 2020 (American journal of physiology. Gastrointestinal and liver physiology), a journal based in United States.

More context: the Secretin compound page.