Effect of Calcium and Vitamin D Co-supplementation on Blood Pressure: A Systematic Review and Meta-Analysis.

What It Covers

Researchers studied Vitamin D, K2, Magnesium and Zinc in the context of low blood pressure and orthostatic hypotension in this meta-analysis publication.

Vitamin D and calcium insufficiency has been related to elevated blood pressure (BP) and cardiovascular complications.

This systematic review and meta-analysis investigates the effect of calcium and vitamin D co-supplementation on BP.

Who the Included Studies Covered

Randomized controlled trials, using calcium and vitamin D co-supplementation and reporting mean systolic BP and/or diastolic BP (DBP) with SDs, were included in the systematic review.

Articles were evaluated independently by 2 researchers based on inclusion and exclusion criteria.

How the Review Was Done

A systematic search was conducted of electronic databases, including Web of Sciences, MEDLINE, Scopus, EMBASE, and the Cochrane Library, along with searches of gray literature and reference lists from included trials.

There were no language restrictions, and the databases were searched from inception to October 2019.

A random effects model was conducted to synthesize the data.

What Was Measured

The subject headings attached to it are Blood Pressure, Calcium, Dietary Supplements, Hypertension and Vitamin D.

The authors tagged it with the keywords diastolic blood pressure and systolic blood pressure.

What This Means in Plain Language

This is a meta-analysis of Vitamin D, K2, Magnesium and Zinc in people with low blood pressure and orthostatic hypotension.

Results are reported in around 6 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (Clinical therapeutics), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Low blood pressure and orthostatic hypotension research.