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Efficacy and safety of a supplement combination for hand osteoarthritis pain: protocol for an internet-based randomised placebo-controlled trial (The RADIANT study)
Plain-language guide to PMID 32075845 (2020): randomized and double-blind clinical study of DMSO (dimethyl sulfoxide, non-peptide solvent).
Key Facts
- PMID
- 32075845
- Journal
- BMJ open
- Year
- 2020
- Study type
- Clinical Study
- Authors
- Liu X et al. (8 authors)
- DOI
- 10.1136/bmjopen-2019-035672
What This Study Did, in Plain Language
What Was Tested
Researchers studied DMSO (dimethyl sulfoxide, non-peptide solvent) in this clinical study publication.
Hand osteoarthritis (HOA) is a highly prevalent disabling joint disease.
The current management regimens are limited.
Who Took Part
Main secondary outcomes include adverse events, change in hand function, patient global assessment of disease activity and quality of life.
A range of additional measures will be recorded, and an individual patient placebo response will be performed.
How the Study Was Run
In design terms this was a randomized, double-blind, placebo-controlled and parallel-group study.
The participants were allocated by chance, so the DMSO (dimethyl sulfoxide, non-peptide solvent) group and the comparison group should start out alike.
As a double-blind DMSO (dimethyl sulfoxide, non-peptide solvent) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with DMSO (dimethyl sulfoxide, non-peptide solvent) could be set against what happens without it.
Groups ran in parallel: each of the participants stayed in one arm throughout.
A participatory design is used to facilitate the study procedures.
The primary outcome will be 12-week change in hand pain on a visual analogue scale (VAS).
The primary analysis will be conducted using an intention-to-treat approach.
What Was Measured
PubMed files the paper under topics including Australia, Curcumin, Dimethyl Sulfoxide, Hand, Internet, Osteoarthritis and Pain Management.
Author keywords: clinical trials, hand & wrist, musculoskeletal disorders and rheumatology.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of DMSO (dimethyl sulfoxide, non-peptide solvent).
The publication is from 2020 (BMJ open), a journal based in England.
More context: the DMSO (dimethyl sulfoxide, non-peptide solvent) compound page, all human trials.
Our Notes on the Compound
DMSO (dimethyl sulfoxide, non-peptide solvent): A solvent that carries substances through skin and into the blood, described as a free-radical scavenger; not a peptide.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.