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Effect of High-Dose vs Standard-Dose Vitamin D Supplementation in Pregnancy on Bone Mineralization in Offspring Until Age 6 Years: A Prespecified Secondary Analysis of a Double-Blinded, Randomized Clinical Trial.

Plain-language guide to PMID 32091548 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 584 children.

Key Facts

PMID
32091548
Journal
JAMA pediatrics
Year
2020
Study type
Randomized Controlled Trial
Authors
Brustad N et al. (10 authors)
DOI
10.1001/jamapediatrics.2019.6083
Registered trial
NCT00856947

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Who Took Part

The study group was 584 children.

By PubMed's age tags, the people studied were infants, young children, children and adults, both men and women.

A prespecified analysis of a double-blinded, randomized clinical trial in the Copenhagen Prospective Studies on Asthma in Childhood 2010 mother-child cohort that included 623 pregnant mothers and their 584 children.

How the Study Was Run

In design terms this was a randomized and double-blind study.

Because people in this Vitamin D, K2, Magnesium and Zinc study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Blinding on both sides kept the children and researchers unaware of who received Vitamin D, K2, Magnesium and Zinc.

Data were analyzed between January 2019 and September 2019.

What Was Measured

PubMed files the paper under topics including Anthropometry, Bone Density, Denmark and Vitamin D.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 584 children.

With several hundred people or more, it is a fairly large study for this kind of research.

The abstract goes on to report its results in about 9 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (JAMA pediatrics), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Related Pages

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.