Daily Preventive Zinc Supplementation Decreases Lymphocyte and Eosinophil Concentrations in Rural Laotian Children from Communities with a High Prevalence of Zinc Deficiency: Results of a Randomized Controlled Trial.

Plain-language guide to PMID 32119742 (2020): randomized controlled trial of Vitamin D, K2, Magnesium and Zinc.

Key Facts

PMID: 32119742
Journal: The Journal of nutrition
Year: 2020
Study type: Randomized Controlled Trial
Authors: Kewcharoenwong C et al. (13 authors)
DOI: 10.1093/jn/nxaa037
Registered trial: NCT02428647

What This Study Did, in Plain Language

What Was Tested

The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.

The effect of zinc supplementation on immune function in young Laotian children was investigated.

Why It Was Studied

Zinc deficiency impairs immune function and is common among children in South-East Asia.

Who Took Part

The age groups tagged for this paper are infants.

Endline means were compared via ANCOVA, controlling for the baseline value of the outcome, child age and sex, district, month of enrollment, and baseline zinc status (below, or above or equal to, the median plasma zinc concentration).

How the Study Was Run

The researchers set it up as a randomized and placebo-controlled study.

The participants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

These interventions continued for 9 mo.

Cytokine production from whole blood cultures, the concentrations of T-cell populations, and a complete blood count with differential leukocyte count were measured at baseline and endline.

What Was Measured

The subject headings attached to it are Deficiency Diseases, Dietary Supplements, Eosinophils, Laos, Lymphocytes, Prevalence and Rural Population.

Author keywords: T-cell concentration, children, complete blood count, cytokine production and zinc supplementation.

What This Means in Plain Language

The paper is a randomized and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc.

Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (The Journal of nutrition), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.