Less Blood Loss by Earlier Oxytocin Infusion in Cesarean Sections? A Randomized Controlled Trial

What Was Tested

Researchers studied Oxytocin in this randomized controlled trial publication.

The aim of their study was to evaluate the positive effect of starting an IV oxytocin infusion early before uterine incision on intraoperative blood loss.

Why It Was Studied

Das Ziel unserer Studie war es. die positive Wirkung der beginnenden IV Oxytocin-Infusion früh vor der Uterusinzision auf den intraoperativen Blutverlust zu bewerten.

Unsere Ergebnisse legen nahe, dass die beginnende intravenöse Oxytocin-Infusion früh vor der Uterusinzision den intraoperativen Blutverlust verringert.

Who Took Part

The abstract describes 101 women taking part.

PubMed tags the participants as women only.

A total of 101 women between 18-40 years who underwent a primary elective cesarean section (CS) were included in this randomized controlled trial.

The patients were divided into two groups.

How the Study Was Run

In design terms this was a randomized study.

Random assignment meant chance, not the researchers, decided who got Oxytocin and who got the comparison, which limits bias.

In Group I (n=51), oxytocin infusion was administered immediately after incision of the visceral peritoneum during CS.

In Group II (n=50), infusion was administered immediately after clamping the umbilical cord.

The primary outcome was the mean volume of blood loss during CS.

In diese randomisierte kontrollierte Studie wurden insgesamt 101 Frauen zwischen 18 und 40 Jahren eingeschlossen, die sich einem primären elektiven Kaiserschnitt unterzogen hatten.

Die Patienten wurden in 2 Gruppen eingeteilt.

What Was Measured

Zu den sekundären Ergebnissen gehörte die mittlere Verringerung der Hämoglobin- und Hämatokritwerte, Bedarf an zusätzlichen Uterotonika und hämostatischen Uterusnähten, Bluttransfusion, postoperativer Schmerzscore und zusätzliche chirurgische Eingriffe.

Topics PubMed links to this paper include Blood Loss, Surgical, Cesarean Section, Oxytocics and Oxytocin.

What This Means in Plain Language

The paper is a randomized study of Oxytocin in 101 women.

The abstract goes on to report its results in about 4 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (Zeitschrift fur Geburtshilfe und Neonatologie), a journal based in Germany.

More context: the Oxytocin compound page.