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Inflammation (IL-1β) Modifies the Effect of Vitamin D and Omega-3 Long Chain Polyunsaturated Fatty Acids on Core Symptoms of Autism Spectrum Disorder-An Exploratory Pilot Study‡.
Plain-language guide to PMID 32121236 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 67 children.
Key Facts
- PMID
- 32121236
- Journal
- Nutrients
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Mazahery H et al. (10 authors)
- DOI
- 10.3390/nu12030661
What This Study Did, in Plain Language
What Was Tested
The paper reports a study of Vitamin D, K2, Magnesium and Zinc, published as a randomized controlled trial.
The Social Responsiveness Scale (SRS) questionnaire was used to assess core symptoms of ASD (baseline, 12-month).
Why It Was Studied
The response to treatment with these nutrients is heterogenous and may be influenced by inflammatory state.
As an exploratory analysis, the researchers investigated whether inflammatory state would modulate the effect of these nutrients on core symptoms of ASD.
Who Took Part
The study group was 67 children.
PubMed indexes the participants as young children and children, both men and women.
How the Study Was Run
The design is described as randomized, double-blind, placebo-controlled and pilot.
The children were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.
As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.
Some children received a placebo instead of Vitamin D, K2, Magnesium and Zinc, giving a reference point.
It is described as a pilot, a small early test of whether a larger Vitamin D, K2, Magnesium and Zinc study would be practical.
What Was Measured
Mixed model repeated measure analyses (including all children or only children with elevated IL-1β) were used.
PubMed files the paper under topics including Autism Spectrum Disorder, Fatty Acids, Omega-3, Inflammation, Interleukin-1beta, Pilot Projects, Surveys and Questionnaires and Vitamin D.
Author keywords: interleukin 1 and intervention.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 67 children.
Results are reported in around 4 sentences of the abstract; we leave them to the paper itself rather than summarise them.
The publication is from 2020 (Nutrients), a journal based in Switzerland.
More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.
Our Notes on the Compound
Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.