Free vitamin D correlate better with bone mineral density and thoracolumbar junction osteoporotic vertebral fractures than serum vitamin D.

What Was Tested

This clinical trial looks at Vitamin D, K2, Magnesium and Zinc in the context of osteoporosis and bone density.

Therefore, the aim of the present study is to analyse if free vitamin D correlates with BMD and osteoporotic fragile vertebral fractures in the elderly population.

To evaluate the association with osteoporotic vertebral multivariate logistic regression model was used.

Why It Was Studied

However, the association between serum vitamin D status, bone mineral density (BMD) and the incidence of vertebral fractures (OVFs) remain controversial.

It is believed that free portion of the circulating vitamin D carries the metabolic activities of vitamin D.

Who Took Part

The study group was 90 patients.

The age groups tagged for this paper are middle-aged adults and older adults, both men and women.

A total of 90 consecutive patients, including 81 female and 9 male patients, aged > 48 years, were included in this cross sectional study between March and July of 2018.

How the Study Was Run

Total vitamin D (total 25(OH)D), free vitamin D (free 25(OH)D), calcium and phosphorus were measured.

BMD was measured using dual energy X-ray absorptiometry (DEXA) and osteoporotic vertebral fracture was assessed using plain radiograph.

Multiple linear regression was performed to find out the association between total vitamin D, free vitamin D and BMD at various sites.

What Was Measured

The subject headings attached to it are Absorptiometry, Photon, Bone Density, Cross-Sectional Studies, Logistic Models, Lumbar Vertebrae, Multivariate Analysis and Osteoporotic Fractures.

Author keywords: Bone mineral density, Free vitamin D, Osteoporosis, Thoracolumbar junction vertebral fractures and Total vitamin D.

What This Means in Plain Language

This is a clinical trial of Vitamin D, K2, Magnesium and Zinc in 90 patients in people with osteoporosis and bone density.

Results are reported in around 8 sentences of the abstract; we leave them to the paper itself rather than summarise them.

The publication is from 2020 (BMC musculoskeletal disorders), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, Osteoporosis and bone density research.