Oral Vitamin D Supplementation to Mothers During Lactation-Effect of 25(OH)D Concentration on Exclusively Breastfed Infants at 6 Months of Age: A Randomized Double-Blind Placebo-Controlled Trial.

Plain-language guide to PMID 32181677 (2020): double-blind randomized controlled trial of Vitamin D, K2, Magnesium and Zinc in 132 infants.

Key Facts

PMID: 32181677
Journal: Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine
Year: 2020
Study type: Randomized Controlled Trial
Authors: Trivedi M et al. (5 authors)
DOI: 10.1089/bfm.2019.0102

What This Study Did, in Plain Language

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Objective: To find out proportion of exclusively breastfed infants having serum 25(OH)D concentration <11 ng/mL at 6 months of age with or without oral supplementation of vitamin D3 to lactating mothers.

Why It Was Studied

Background: Exclusively breastfed infants are at risk of vitamin D deficiency.

Methods: Randomized placebo-controlled study included 132 mothers and infants divided into two groups.

Who Took Part

According to the abstract, 132 infants were involved.

PubMed indexes the participants as infants and adults, women only.

Serum 25(OH)D concentration in the mothers was measured at recruitment and that of infants, at birth and 6 months.

How the Study Was Run

In design terms this was a randomized, double-blind and placebo-controlled study.

Random assignment meant chance, not the researchers, decided who got Vitamin D, K2, Magnesium and Zinc and who got the comparison, which limits bias.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

The comparison arm used a placebo, so changes seen with Vitamin D, K2, Magnesium and Zinc could be set against what happens without it.

Infants were evaluated for rickets at 6 months.

What Was Measured

The subject headings attached to it are Breast Feeding, Dietary Supplements, Lactation, Mothers and Vitamin D.

The authors tagged it with the keywords breastfeeding, infants, rickets and vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Vitamin D, K2, Magnesium and Zinc in 132 infants.

The publication is from 2020 (Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine), a journal based in United States.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.

Our Notes on the Compound

Vitamin D, K2, Magnesium and Zinc: Magnesium is described as required for AMPK to function.

Vitamin D, K2, Magnesium and Zinc in the library

Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.