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Vitamin D3 Supplementation in Diarrhea-Predominant Irritable Bowel Syndrome Patients: The Effects on Symptoms Improvement, Serum Corticotropin-Releasing Hormone, and Interleukin-6 - A Randomized Clinical Trial
Plain-language guide to PMID 32203968 (2020): double-blind randomized controlled trial study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Key Facts
- PMID
- 32203968
- Journal
- Complementary medicine research
- Year
- 2020
- Study type
- Randomized Controlled Trial
- Authors
- Khalighi Sikaroudi M et al. (9 authors)
- DOI
- 10.1159/000506149
What This Study Did, in Plain Language
What Was Tested
Researchers studied ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone) in this randomized controlled trial publication.
Who Took Part
The age groups tagged for this paper are teenagers, young adults, adults, middle-aged adults and older adults, both men and women.
Eighty-eight IBS-D patients (age: 18-65 years) based on Rome IV criteria who suffered from vitamin D deficiency and/or insufficiency were enrolled in this randomized, placebo-controlled trial from February 2017 to May 2018 at Rasoul-e-Akram Hospital, Tehran, Iran.
Participants were randomly divided into two groups.
How the Study Was Run
In design terms this was a randomized, double-blind and placebo-controlled study.
Because people in this ACTH (Corticotropin) study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.
As a double-blind ACTH (Corticotropin) study, the assignments were hidden from both participants and investigators until the end.
The comparison arm used a placebo, so changes seen with ACTH (Corticotropin) could be set against what happens without it.
The IBS Severity Score System (IBS-SSS), serum 25(OH) vitamin D3, CRH, and IL-6 were measured before and after interventions.
What Was Measured
Topics PubMed links to this paper include Biomarkers, Cholecalciferol, Corticotropin-Releasing Hormone, Diarrhea, Dietary Supplements, Interleukin-6 and Irritable Bowel Syndrome.
Author keywords: Clinical symptoms and Vitamin D3.
What This Means in Plain Language
The paper is a randomized, double-blind and placebo-controlled study of ACTH (Corticotropin) and CRH (Corticotropin-Releasing Hormone).
Its findings take up roughly 5 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.
The publication is from 2020 (Complementary medicine research), a journal based in Switzerland.
More context: the ACTH (Corticotropin) compound page and the CRH (Corticotropin-Releasing Hormone) compound page, all human trials.
Our Notes on the Compounds
ACTH (Corticotropin): The 39-amino-acid pituitary hormone that drives cortisol production; given as repository corticotropin (Acthar Gel).
CRH (Corticotropin-Releasing Hormone): The 41-amino-acid hypothalamic hormone that triggers ACTH release; corticorelin is used diagnostically.
Related Pages
Source: PubMed record. This explanation is written by PeptideWhiz from the public record. For research and education only. Not medical advice; no dosing information is given.