Circulating Insulin-Like Growth Factor-1 Is Positively Associated with Growth and Cognition in 6- to 9-Year-Old Schoolchildren from Ghana

What Was Tested

The paper reports a study of IGF-1 LR3, published as a randomized controlled trial.

The objective was to assess the effect of milk supplement on circulating IGF-1 and to assess IGF-1 as a correlate of growth and cognition in children.

Linear regressions were used to assess the effect of milk interventions on IGF-1 and IGF-1 as a correlate of growth and cognition.

Why It Was Studied

These effects may be mediated through insulin-like growth factor-1 (IGF-1).

Who Took Part

PubMed indexes the participants as children, both men and women.

Secondary data on blood spot IGF-1 from a randomized, double-blind, controlled trial in 6-9-y-old children from rural Ghana were analyzed.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

Because people in this IGF-1 LR3 study were split into groups at random, differences between the groups are less likely to reflect who happened to join each one.

Neither the participants nor the staff measuring them knew who was on IGF-1 LR3, so expectations could not easily colour the readings.

IGF-1, length, body composition, and Cambridge Neuropsychological Test Automated Battery (CANTAB) were measured at 3.5 or 8.5 mo.

What Was Measured

Topics PubMed links to this paper include Amino Acids, Body Composition, Cognition, Dietary Supplements, Dried Blood Spot Testing, Ghana and Growth.

The authors tagged it with the keywords Africa, children, insulin-like growth factor-1 (IGF-1), low-income country and milk.

What This Means in Plain Language

The paper is a randomized and double-blind study of IGF-1 LR3.

Its findings take up roughly 8 sentences of the abstract and are left out here on purpose; the source paper is the place to read them.

The publication is from 2020 (The Journal of nutrition), a journal based in United States.

More context: the IGF-1 LR3 compound page, all human trials.