Serum levels of Homocysteine, Vitamin B12 and Folate in Patients with Multiple Sclerosis: an Updated Meta-Analysis.

What It Covers

This meta-analysis looks at Cyanocobalamin (Vitamin B12) in the context of multiple sclerosis.

Methods: In this study, the researchers aimed to investigate the relationships between MS and Hcy, Vitamin B12 and folate with updated available data (until September, 2019).

After data collection, separate analyses based on random-effect models were used to test for relationships between MS and Hcy, Vitamin B12 or folate blood levels.

Why It Was Studied

Background: Multiple sclerosis (MS) is a demyelinating and disabling inflammatory disease of the central nervous system.

MS is triggered by complex environmental factors which mostly affect genetically the susceptible young people.

Who the Included Studies Covered

By PubMed's age tags, the people studied were adults and middle-aged adults, both men and women.

Results: Based on the inclusion criteria, a total of 21 original studies with 1738 MS patients and 1424 controls were included in this study.

What Was Measured

The diagnosis of MS was performed based on international criteria for the diagnosis of MS, including magnetic resonance imaging and cerebrospinal fluid tests.

There were 17 studies for measuring Hcy, 16 studies for measuring Vitamin B12 and 13 studies for measuring folate in patients with MS, respectively.

The subject headings attached to it are Case-Control Studies, Disease Progression, Folic Acid, Homocysteine, Multiple Sclerosis and Vitamin B 12.

The authors tagged it with the keywords Folate, Meta-analysis and Vitamin B12.

What This Means in Plain Language

This is a meta-analysis of Cyanocobalamin (Vitamin B12) in people with multiple sclerosis.

The publication is from 2020 (International journal of medical sciences), a journal based in Australia.

More context: the Cyanocobalamin (Vitamin B12) compound page, Multiple sclerosis research.