Adherence to treatment in children with growth hormone deficiency, small for gestational age and Turner syndrome in Mexico: results of the Easypod™ connect observational study (ECOS).

What Was Tested

The paper reports a study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over), published as an observational study.

ECOS (NCT01555528) was a multicenter (24 countries), 5-year, longitudinal, observational study, which aimed to evaluate country-specific adherence to r-hGH therapy prescribed via the Easypod™ electronic injection device.

Why It Was Studied

Assessing adherence to growth hormone (GH) is challenging.

The researchers assessed adherence to r-hGH delivered with Easypod™ according to the approved pediatric indications for r-hGH: growth hormone deficiency (GHD), born small for gestational age (SGA) who failed to show catch-up growth and Turner syndrome (TS).

Who Took Part

By PubMed's age tags, the people studied were children and teenagers, both men and women.

How the Study Was Run

The researchers set it up as a multicenter study.

Running at several centres spread the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) study over different clinics and patient groups.

The primary endpoint was yearly adherence.

Secondary endpoints were height velocity, height velocity standard deviation scores (SDS), height, height SDS and IGF-1 concentrations.

Clinical and auxological data were obtained from medical records and adherence from Easypod™ logs.

What Was Measured

Assessing adherence to growth hormone (GH) is challenging.

The researchers assessed adherence to r-hGH delivered with Easypod™ according to the approved pediatric indications for r-hGH: growth hormone deficiency (GHD), born small for gestational age (SGA) who failed to show catch-up growth and Turner syndrome (TS).

Topics PubMed links to this paper include Dwarfism, Pituitary, Growth Disorders, Hormone Replacement Therapy, Human Growth Hormone, Infant, Small for Gestational Age, Longitudinal Studies and Mexico.

The authors tagged it with the keywords Adherence, Auto-injector, Device and Somatotropin.

What This Means in Plain Language

The paper is a multicenter study of Exogenous HGH, sermorelin & older GHRPs (why they're passed over).

The abstract goes on to report its results in about 10 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (Journal of endocrinological investigation), a journal based in Italy.

More context: the Exogenous HGH, sermorelin & older GHRPs (why they're passed over) compound page, all human trials.