Greater lactate accumulation following an acute bout of high-intensity exercise in males suppresses acylated ghrelin and appetite postexercise

What Was Tested

This randomized controlled trial paper looks at Ghrelin.

Given lactate may mediate these effects, the researchers used sodium bicarbonate (NaHCO3) supplementation in a double-blind, placebo-controlled, crossover design to investigate lactate's purported role in exercise-induced appetite suppression.

Why It Was Studied

High-intensity exercise inhibits appetite, in part, via alterations in the peripheral concentrations of the appetite-regulating hormones acylated ghrelin, active glucagon-like peptide-1 (GLP-1), and active peptide tyrosine-tyrosine (PYY).

Who Took Part

PubMed tags the participants as men only.

How the Study Was Run

The design is described as randomized, double-blind, placebo-controlled and crossover.

Random assignment meant chance, not the researchers, decided who got Ghrelin and who got the comparison, which limits bias.

As a double-blind Ghrelin study, the assignments were hidden from both participants and investigators until the end.

A placebo (an inactive look-alike) gave the Ghrelin group a baseline to be compared against.

In the crossover set-up each of the participants took both Ghrelin and the comparison in turn, acting as their own control.

Blood lactate, acylated ghrelin, GLP-1, and PYY concentrations, as well as overall appetite were assessed preexercise and 0, 30, 60, and 90 min postexercise.

What Was Measured

PubMed files the paper under topics including Appetite, Exercise, Ghrelin, Lactic Acid and Peptide YY.

Author keywords: anorexigenic, appetite regulation, gut peptides, high-intensity interval training and orexigenic.

What This Means in Plain Language

The paper is a randomized, double-blind and placebo-controlled study of Ghrelin.

The publication is from 2020 (Journal of applied physiology (Bethesda, Md. : 1985)), a journal based in United States.

More context: the Ghrelin compound page, all human trials.