In infants with sufficient vitamin D status at birth, vitamin D supplementation does not impact immune development.

What Was Tested

Researchers studied Vitamin D, K2, Magnesium and Zinc in this randomized controlled trial publication.

Vitamin D has potent immunomodulatory properties, but the mechanisms remain unclear.

The researchers have investigated the effect of oral vitamin D supplementation on circulating immune cell phenotypes in infants.

Who Took Part

The study group was 78 infants.

By PubMed's age tags, the people studied were infants, women only.

How the Study Was Run

The researchers set it up as a randomized and double-blind study.

The infants were allocated by chance, so the Vitamin D, K2, Magnesium and Zinc group and the comparison group should start out alike.

As a double-blind Vitamin D, K2, Magnesium and Zinc study, the assignments were hidden from both participants and investigators until the end.

A subset of 78 infants was included in this analysis.

Phenotypic analysis of immune cell subsets was performed using flow cytometry.

What Was Measured

The subject headings attached to it are Cholecalciferol, Dietary Supplements, Eczema, Vitamin D, Vitamin D Deficiency and Vitamins.

Author keywords: early life, immune cell profiles, randomised controlled trial and vitamin D supplementation.

What This Means in Plain Language

The paper is a randomized and double-blind study of Vitamin D, K2, Magnesium and Zinc in 78 infants.

The abstract goes on to report its results in about 6 sentences; this page does not restate them, so read the paper for the findings and their limits.

The publication is from 2020 (Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology), a journal based in England.

More context: the Vitamin D, K2, Magnesium and Zinc compound page, all human trials.